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The H-bond interaction, hydrophobic interaction, electrostatic interaction and binding energies of ACLY with the compounds are as follows: oleocanthal (-6.1 kcal/mol, H-bond interaction: GLY281, SER343, ASN346, GLY664, GLY665), hydrophobic interaction: ALA280, ALA345, electrostatic interaction: no), oleacein (-6.0 kcal/mol, H-bond interaction: GLY309, ASN346, VAL626, GLY664, GLY665), hydrophobic interaction: ALA345, PHE347 electrostatic interaction: no), luteolin (-8.6 kcal/mol), H-bond interaction: SER7, ARG33, ASP60, GLN61, PHE242, GLY243, GLU245, ALA246, hydrophobic interaction: PRO239, PRO240, electrostatic interaction: no), Tyrosol (-5.3 kcal/mol, H-bond interaction: ASN346, PHE347, THR348, hydrophobic interaction: no, electrostatic interaction: no), ezetimibe ( 6.0 kcal/mol, H-bond interaction: GLU250, hydrophobic interaction: PRO241 (Figs

The skin has a particularly complicated connection with the gut, but the underlying mechanism is still completely understood, and this phenomenon is at least partially attributed to the disruption of the intestinal barrier (Kim et al., 2014